The Integrative Medicine Institute has led a variety of research projects collecting data from providers and patients on effectiveness, satisfaction, safety, and cost. Dr. Riley has continued this collaboration through his work on case reports, clinical trials and their publication in medical journals.

In the 1990s the Institute created international data collection networks linking healthcare practitioners, patients, and academic medical centers in Europe and the United States.  This was done through a series of practice-based research projects: International Integrative Primary Care Outcomes Studies 1 and 2, and an international Integrative Medicine Data Collection Network (IMDCN 2001). The International Integrative Primary Care Outcomes Study (Riley 2001) was a prospective outcomes study with data was systematically collected on effectiveness, safety, and cost in a practice based setting. (Riley D, 2001).

Other areas of research have included: